Particle and fibre toxicology 11, 17 (2014). Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release. Cellular responses induced by silver nanoparticles: In vitro studies. Mutation Research-Genetic Toxicology and Environmental Mutagenesis 726, 129–135 (2011).Īrora S., Jain J., Rajwade J. Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells. The virus is transmitted not only from an infected doe to her kid in the colostrum and milk, but also by direct contact transmission. These diseases are caused by a group of lentiviruses called the small ruminant lentiviruses (SRLVs). 1721, 77 In addition to causing a demyelinating leukoencephalitis of young goats, this virus causes pneumonitis, arthritis, and mastitis of older adult goats. Maedi-visna and caprine arthritis and encephalitis are economically important viral diseases that affect sheep and goats. Nanosilver: A nanoproduct in medical application. Caprine arthritis encephalitis (CAE) is a multisystem viral disease of goats caused by a lentivirus, a type-C retrovirus that is related to the visna virus of sheep. Controlled Release of Biologically Active Silver from Nanosilver Surfaces. Hence, the present results indicate that intracellular Ag 2S formation, resulting from CSE-mediated H 2S production in microglia, sequesters Ag + ions released from AgNPs, significantly limiting their toxicity, concomitantly reducing microglial inflammation and related neurotoxicity. syndrome / rheumatoid pneumoconiosis : silicosis + rheumatoid arthritis. The disease is characterized by progressive inflammation and persistent synovitis, leading to bone and cartilage destruction, functional incapability, and ultimately disability 2,3. Complications : postasphyxial hypoxic-ischemic encephalopathy (HIE) : Sarnat HB. In addition, AgNPs showed significant anti-inflammatory effects, reducing lipopolysaccharide (LPS)-stimulated ROS, nitric oxide and TNFα production, which translated into reduced microglial toxicity towards dopaminergic neurons. Rheumatoid arthritis (RA) is a type of chronic auto-immune disorder that affects 1 of the adult population. ![]() Furthermore, AgNP-treatment up-regulated microglial expression of the hydrogen sulphide (H 2S)-synthesizing enzyme cystathionine-γ-lyase (CSE). ![]() Analytical microscopy demonstrated internalization and dissolution of AgNPs within microglia and formation of non-reactive silver sulphide (Ag 2S) on the surface of AgNPs. In the present study, the in vitro uptake and intracellular transformation of citrate-capped AgNPs by microglia, as well as their effects on microglial inflammation and related neurotoxicity were examined. In addition, understanding AgNP processing by microglia will allow better prediction of their long term bioreactivity. ![]() Given microglia are implicated in neurodegenerative disorders such as Parkinson's disease (PD), it is important to examine how AgNPs affect microglial inflammation to fully assess AgNP neurotoxicity. However, there is a paucity in studies examining the effect of AgNP on the resident immune cells of the brain, microglia. Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal death.
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